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目的探讨血清肌酸激酶同工酶(CK-MB)检测在手足口病诊治中的价值。方法回顾性分析本院2011年10月至2012年10月收治的手足口病140例,每位患儿均检测了CK-MB,CK-MB≤25U/L72例为A组,CK-MB>25 U/L68例为B组,对比分析2组的临床特点。结果与A组比较,B组发热峰值明显升高,热程明显延长,呕吐病例、呼吸增快病例、心率增快病例明显增加(P<0.01),心肌炎病例增多,中枢神经系统损害病例增多(P<0.05),血白细胞平均值明显升高(P<0.01),血糖升高病例、ALT升高病例、血乳酸升高病例、心电图异常病例、胸片异常病例明显增多(P<0.01或P<0.05)。结论手足口病可以出现心肌损害,合并心肌损害的手足口病患儿病情更严重,常规检测CK-MB有利于对手足口病病情的评估。
Objective To investigate the value of serum creatine kinase isoenzyme (CK-MB) in the diagnosis and treatment of hand-foot-mouth disease. Methods Retrospective analysis of 140 patients with hand-foot-mouth disease admitted to our hospital from October 2011 to October 2012, CK-MB was detected in each child, group A was 72 cases with CK-MB≤25U / L, CK-MB> 25 U / L68 cases of B group, comparative analysis of two groups of clinical features. Results Compared with group A, the peak fever in group B was significantly increased and the heat duration was significantly prolonged. Vomiting, respiratory rate and heart rate were significantly increased in group B (P <0.01), the number of myocarditis increased, and the number of central nervous system damage increased (P <0.01). The average value of blood leucocyte was significantly increased (P <0.01). The incidence of hyperglycemia, elevated ALT, elevated blood lactate, abnormal electrocardiogram and abnormal chest radiographs were significantly increased (P <0.01 or P <0.05). Conclusion Hand-foot-and-mouth disease can cause myocardial damage. Children with hand-foot-mouth disease complicated with myocardial damage are more serious. The routine examination of CK-MB is helpful for the evaluation of the disease of hand-foot-mouth disease.