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下钙素(Katacalcin)是一种新发现的具有降低血钙效应的多肽激素,这是首先用DNA重组技术、后用肽合成方法证明其存在并阐明其一级结构的第一个激素。下钙素与降钙素来自同一前体蛋白,这一前体蛋白的结构如下:缬-亮-亮-丙-丙-亮-缬-谷-胺-天-酪-缬-谷胺-蛋-赖-丙-丝-谷-亮-谷-谷胺-谷-谷胺-谷-精-谷-甘-丝-丝-亮-天-丝-脯-精-丝-赖-精-半胱-甘-天胺-亮-丝-苏-半胱-蛋-亮-甘-苏-酪-苏-谷胺-天-苯-天胺-赖-苯-组-苏-苯-脯-谷胺-苏-丙-异亮-甘-缬-甘-丙-脯-甘-赖-赖-精-天-蛋-丝-丝-天-亮-谷-精-天-组-精-脯-组-缬-丝-蛋-脯-谷胺-天胺-丙-天胺其中1～34的多肽的作用尚不清楚,37～68(三十二肽)为降钙素,73～93(二十一肽)为下钙素。
Katacalcin, a newly discovered polypeptide hormone with a reduced blood calcium effect, is the first hormone to be first identified by DNA recombination techniques and then peptide-synthesized to demonstrate its presence and elucidate its primary structure. Calcium and calcitonin are derived from the same precursor protein. The structure of this precursor protein is as follows: Valerian-Bright-Bright-Prop-Prop-Bromo-Valerian-Amine- - Lai - C - silk - Valley - bright - Valley - Valley amine - Valley - Valley amine - Valley - refined - Valley - Gan - silk - silk - bright - day - silk - preserved - fine - silk - Lai - refined - half Cystamine Glycerine - Tian - amine - Tian - amine - Lai - benzene - group - Su - benzene - preserved - Glutamine-threo-propane-isole-glycero-valine-glycero-propane-propionanilide- The effect of the polypeptide of 1 to 34 is unclear. 37-68 (thirty-two peptide) is calcitonin, 93 (twenty-one peptide) is calcitonin.