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目的：观察人反义IGF－Ⅰ基因转移对抑制血管平滑肌细胞增殖的效果。方法：将反义IGF-Ⅰ基因转导至大鼠球囊损伤的颈动脉再狭窄模型中，21天后观察其对新生内膜形成的影响。结果：与对照组相比，损伤血管新生内膜／中层面积比降低了41％（P＜0．001）。结论：反义人IGF-Ⅰ基因治疗可能对血管成形术后再狭窄有一定的预防作用。
Objective: To observe the effect of human antisense IGF-Ⅰ gene transfer on the inhibition of vascular smooth muscle cell proliferation. Methods: The antisense IGF-Ⅰ gene was transduced into the model of carotid artery stenosis induced by balloon injury in rats. The effect of antisense IGF-Ⅰ gene on neointima formation was observed after 21 days. Results: Compared with control group, the intima / media area ratio of injured angiogenesis decreased by 41% (P <0.001). Conclusion: Antisense human IGF-Ⅰ gene therapy may have a preventive effect on restenosis after angioplasty.