1978年以来,我们与湖北医药工业研究所协作,对抗血吸虫新药——吡喹酮(Praziquantel,EMBAY8440),进行了抗小白鼠体内日本血吸虫作用的研究,现将结果报告如下。 材料与方法 取体重20～30克的健康小白鼠,经腹部剪毛后,接种日本血吸虫尾蚴40±1条,其后第35天,按800毫克/公斤体重一次灌胃给药,药物用1％西黄蓍胶配制成混悬液,分别于停药后第1、5、14、30天进行剖检。 Since 1978, we cooperated with Hubei Institute of Pharmaceutical Industry to study the anti-Schistosoma japonicum effect against the new schistosome drug Praziquantel (EMBRY8440). The results are reported as follows. MATERIALS AND METHODS: Healthy mice weighing 20-30 g were inoculated with 40 ± 1 cercariae of Schistosoma japonicum after shearing their belly, followed by intragastric administration of 800 mg / kg body weight on the 35th day. The animals were treated with 1% Tragacanth gum was prepared into suspension, respectively, on the 1st,