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目的比较不同年龄组2型糖尿病(T2DM)患者主要促凝、抗凝因子的变化及其与患者年龄的相关性,探讨T2DM患者年龄对凝血功能的影响。方法随机选取2015年1-2月某医院90例不同年龄段T2DM患者为研究对象,测定分析各组患者血浆凝血因子FⅡ,FⅤ,FⅦ,FⅧ,FⅨ,FⅩ,FⅪ,FⅫ、血管性血友病因子抗原(von willebrand factor antigen,v WF:Ag)、抗凝凝血酶Ⅲ(antithrombin III,ATIII)及蛋白C(Protein C,PC)。结果各年龄段T2DM患者FⅡ,FⅤ,FⅧ,FⅩ,FⅪ、PC均正常,各因子活性与年龄不相关(r值分别为-0.182,0.036,0.299,-0.194,0.074及-0.276);FⅦ、FⅨ、FⅫ及ATⅢ含量较正常值范围出现异常,但各因子变化与年龄不相关(r值分别为-0.071,0.255,-0.116及-0.041);70-79岁及80-89岁年龄段患者v WF:Ag含量高于正常值,且研究结果显示v WF:Ag与患者年龄呈正相关(r=0.322)。结论加强血浆FⅦ、FⅨ及FⅫ活性、v WF:Ag及ATⅢ含量的监测,有利于对T2DM患者凝血状态进行评估,从而为防治T2DM患者血管并发症提供参考依据;加强老年T2DM患者v WF监控有利于防治糖尿病并发症及血栓并发症。
Objective To compare the changes of major procoagulant and anticoagulant factors in patients with type 2 diabetes mellitus (T2DM) in different age groups and their correlation with patient age, and to explore the influence of age on the coagulation function in T2DM patients. Methods A total of 90 T2DM patients of different ages in a hospital from January to February in 2015 were enrolled in this study. The levels of plasma coagulation factors FⅡ, FⅤ, FⅦ, FⅧ, FIX, FⅩ, FXI, FⅫ, Von Willebrand factor antigen (vWF: Ag), antithrombin III (ATIII) and protein C (PC). Results FⅡ, FⅤ, FⅧ, F Ⅹ, F Ⅺ and PC were all normal in T2DM patients. The activity of each factor was not correlated with age (r = -0.182,0.036,0.299,0.194,0.074 and -0.276, respectively) The levels of FⅨ, FⅫ and ATⅢ were abnormal compared with the normal range, but the factors were not related to age (r = -0.071,0.255, -0.116 and -0.041, respectively); patients aged 70-79 and 80-89 v WF: Ag levels were higher than normal, and the results showed that vWF: Ag was positively correlated with patient age (r = 0.322). CONCLUSIONS: The monitoring of plasma FⅦ, FⅨ and FⅫ activity, vWF: Ag and ATⅢ levels is helpful to evaluate the coagulation status of patients with T2DM and provide a reference for prevention and treatment of vascular complications in T2DM patients. Conducive to the prevention and treatment of diabetic complications and thrombotic complications.