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植入自动除颤器的患者常常使用胺碘达隆,作为反复发作的室性快速心律失常的辅助治疗。本实验表明即时静脉注射胺碘达隆显著减少除颤所需能量,而长期口服胺碘达隆对除颤所需能量并无显著影响。平均体重23.6(19.5～28.6)kg的12只杂种犬(雌雄不拘),在戊巴比妥钠静脉麻醉下,插管控制呼吸,开胸显露心脏。左室外膜面缝上13.5cm~3的网状钛片(阴极),右房内插入7cm~2的钛弹簧(阳极)。关
Patients with an automated defibrillator often use amiodarone as an adjunct to recurrent ventricular tachyarrhythmias. This experiment shows that immediate intravenous amiodarone significantly reduces the energy required for defibrillation, whereas long term oral administration of amiodarone has no significant effect on the energy required for defibrillation. Twelve mongrel dogs (mean male and female) weighing 23.6 (19.5-28.6) kg were anesthetized with sodium pentobarbital and intubated to control respiration and chest open to reveal the heart. The left ventricular surface sewn 13.5cm ~ 3 mesh titanium (cathode), the right atrium inserted 7cm ~ 2 titanium spring (anode). turn off