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目的观察奥沙利铂联合阿糖胞苷及地塞米松治疗老年非霍奇金淋巴瘤(NHL)的疗效及不良反应。方法 23例老年NHL患者应用奥沙利铂130mg/m2,静脉滴注,第1天;阿糖胞苷2000mg/m2,静脉滴注,q12h,第2天;地塞米松40mg/d,静脉注射,第1天至第4天,每21~28d为1疗程,每例患者至少持续应用3疗程评价疗效。结果可评价的23例患者均完成3~9个周期化疗。治疗有效16例(69.6%),CR10例(43.5%)。最长CR期为28个月,平均缓解时间(19.2±4.3)个月。发生中性粒细胞减少、中性粒细胞缺乏、BPC<20×109/L分别为58次(60.4%)、34次(35.4%)、14次(14.6%)。结论奥沙利铂联合阿糖胞苷及地塞米松治疗老年非霍奇金淋巴瘤有较好的近期疗效,不良反应可以耐受。
Objective To observe the efficacy and side effects of oxaliplatin combined with cytarabine and dexamethasone in the treatment of elderly non-Hodgkin’s lymphoma (NHL). Methods Twenty-three elderly patients with NHL were treated with oxaliplatin 130 mg / m 2 intravenously on day 1, cytarabine 2000 mg / m 2, intravenous drip, q12h on day 2, dexamethasone 40 mg / d, intravenous injection , The first day to the fourth day, every 21 ~ 28d for a course of treatment, each patient sustained application of at least 3 courses evaluation of efficacy. Results All the 23 evaluable patients completed 3 ~ 9 cycles of chemotherapy. Treatment was effective in 16 cases (69.6%), CR10 cases (43.5%). The longest CR period was 28 months and the mean response time was (19.2 ± 4.3) months. Neutropenia, neutropenia, BPC <20 × 109 / L were 58 times (60.4%), 34 times (35.4%), 14 times (14.6%). Conclusion Oxaliplatin combined with cytarabine and dexamethasone in the treatment of elderly non-Hodgkin’s lymphoma has a good short-term efficacy, adverse reactions can be tolerated.