两种类型的大环抗生素对很多外消旋化合物具有显著的手性选择性且手性选择性相互补充 :第一种类型含ansamycin (安沙霉素 )特别适合于阳离子外消旋化合物的分离 ;第二种类型含glycopeptide (糖肽 )最适于阴离子的分离。介绍了大环抗生素的结构特征及手性识别机理 ,讨论了pH值、抗生素类型和浓度、电泳电解质浓度和化学性质、有机改性剂及胶束相等不同实验条件对分离的影响 ,还概述了几种大环抗生素作为手性选择剂 ,在毛细管电泳手性分离中的研究近况。 Both types of macrocyclic antibiotics have significant chiral selectivity and chiral selectivity for many racemic compounds: the first type, ansamycin (ansamycin), is particularly suitable for the separation of cationic racemic compounds; The second type of glycopeptide (glycopeptide) is most suitable for the separation of anions. The structural characteristics and chiral recognition mechanism of macrocyclic antibiotics are introduced. The effects of different experimental conditions such as pH, type and concentration of antibiotics, concentration and chemical nature of electrophoretic electrolyte, organic modifier and micelles are discussed. Several Macrocyclic Antibiotics as Chiral Selective Agents in Chiral Separation by Capillary Electrophoresis.