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37例Ⅱ型糖尿病患者,用克糖尿治疗3～6个月,作前瞻性研究。对治疗前后的有关参数进行比较:治疗后糖代谢改善,血清胰岛素和C肽水平升高(P<0.01);胰升糖素下降(P<0.01);糖基化蛋白、血粘度、血小板聚集率和TXB_2/6-酮PGF_(1α)降低(P<0.05～0.01);血浆支链氨基酸浓度减少,甲皱微循环改善。结果提示:克糖尿可增强胰岛B细胞功能,可能有预防糖尿病血管并发症的作用。对优降糖继发失效者也有效。
Thirty-seven patients with type 2 diabetes were treated with g-glucosidase for 3 to 6 months for prospective study. The relative parameters before and after treatment were compared: the improvement of glucose metabolism, the level of serum insulin and C-peptide (P <0.01), the decrease of glucagon (P <0.01), glycosylated protein, blood viscosity and platelet aggregation (P <0.05 ~ 0.01), the concentration of branched-chain amino acids in plasma decreased, and the microcirculation of nail fold improved. The results suggest that: g diabetes can enhance islet B cell function may have the role of prevention of diabetic vascular complications. It is also effective in patients with secondary hypoglycemic failure.