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目的观察三七皂甙（ＰＮＳ）对大鼠肠系膜微循环的影响。方法１４只大鼠随机分为两组，对照组用生理盐水０．５ｍｌ／１００ｇ，药物组用１０％ＰＮＳ０．４ｍｌ／１００ｇ，连续灌胃１０天后，分别由舌静脉注射无菌新鲜羊水０．２ｍｌ／１００ｇ，造成微循环障碍，并于注射羊水前及注射羊水后即刻、１０、３０分钟分别观察记录微循环各指标的变化。结果对照组在注射羊水前后其微循环各指标差异显著。药物组的血流速度、血流量与注射羊水前比较，注射羊水后即刻有显著性差异（Ｐ＜０．０５），注射后１０、３０分钟无明显差异（Ｐ＞０．０５），但与对照组比较差异显著（Ｐ＜０．０５），药物组的流态、血色、血管壁清晰度在注射羊水后其变化程度较轻。结论ＰＮＳ能预防和改善大鼠肠系膜的微循环障碍，其作用机理可能与对血管内皮细胞的保护及抑制内皮缩血管物质（ＥＤＣＦ）释放和扩散的作用有关。
Objective To observe the effect of panax pseudoginseng (PNS) on mesenteric microcirculation in rats. Methods Fourteen rats were randomly divided into two groups. The control group used normal saline 0.5ml/100g and the drug group used 10% PNS 0.4ml/100g. After continuous intragastric administration for 10 days, sterile fresh amniotic fluid was injected into the tongue vein. 2ml/100g caused microcirculatory disturbances, and the change of each index of the microcirculation was observed immediately before, 10, and 30 minutes after amniotic fluid injection and amniotic fluid injection. Results There were significant differences in the indicators of microcirculation before and after the amniotic fluid injection in the control group. The blood flow velocity and blood flow of the drug group were significantly different from those before amniotic fluid injection (P<0.05) immediately after the injection of amniotic fluid, and there was no significant difference (P>0.05) at 10 and 30 minutes after injection. The difference between the control group and the control group was significant (P<0.05). The flow state, blood color, and vascular wall definition of the drug group were less changed after the amniotic fluid injection. Conclusion PNS can prevent and improve the microcirculatory disturbance of mesentery in rats, and its mechanism of action may be related to the protection of vascular endothelial cells and the inhibition of the release and proliferation of endothelial vasoconstrictor substances (EDCF).