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透明质酸(HA)和Ⅲ型胶原是肝细胞外基质(ECM)的两种成分。在肝细胞外Ⅲ型前胶原合成中,C端和N端氨基肽被分开并可在血清中测到。有人已发现,在急性和慢性肝炎病人的血清中Ⅲ型前胶原N端氨基前肽(P-Ⅲ-NP)水平增高。在慢性肝病中,P-Ⅲ-NP水平主要反应炎性活动度和纤维生成,而HA水平则主要反应慢性肝疾病。作者研究了用α2a-干扰素(α2a-IFN)治疗对慢性HBV感染病人血清HA和P-Ⅲ-NP
Hyaluronic acid (HA) and type III collagen are two components of the extracellular matrix (ECM) of the liver. In extrahepatic type III procollagen synthesis, C-terminal and N-terminal amino peptides are separated and can be detected in serum. It has been found that levels of type III procollagen N-terminal aminopeptidase (P-III-NP) are elevated in the serum of patients with acute and chronic hepatitis. In chronic liver disease, P-III-NP levels mainly reflect inflammatory activity and fibrogenesis, whereas HA levels mainly respond to chronic liver disease. The authors studied the use of interferon alpha (α2a-IFN) in patients with chronic HBV infection serum HA and P-Ⅲ-NP