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目的探讨P53在甲状腺乳头状癌组织中的表达情况及临床意义。方法应用免疫组织化学检测70例甲状腺乳头状癌,56状腺腺瘤组织中P53的表达情况。结果 P53在甲状腺乳头状癌组织中的表达阳性率明显高于甲状腺腺瘤,相比较差异有统计学意义(P<0.01)。P53在甲状腺乳头状癌组织中的表达与性别、年龄、肿瘤大小、结节数量无关(P>0.05)。结论 P53在甲状腺乳头状癌中的表达增高,对临床上评估甲状腺乳头状癌的的发生、发展及预后的关系具有重要临床意义。
Objective To investigate the expression of P53 in papillary thyroid carcinoma and its clinical significance. Methods Immunohistochemistry was used to detect the expression of P53 in 70 cases of thyroid papillary carcinoma and 56 cases of adenomatous adenoma. Results The positive rate of P53 in thyroid papillary carcinoma was significantly higher than that in thyroid adenoma (P <0.01). The expression of P53 in papillary thyroid carcinoma was not related to gender, age, tumor size and nodule number (P> 0.05). Conclusion The expression of P53 in papillary thyroid carcinoma is increased, which has important clinical significance in the evaluation of the occurrence, development and prognosis of thyroid papillary carcinoma.