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使用二维凝胶电泳(2 DE)、质谱和生物信息学技术,发现多种蛋白(如CagA,GroEL,TsaA等)与幽门螺杆菌的致胃癌机制有关;并找到了一些胃癌细胞株和胃癌组织的特异性蛋白,如ErbB3,annexinV,prohibitin等;证明了丙酮酸激酶M2蛋白等胃癌耐药相关蛋白的存在。
Using two-dimensional gel electrophoresis (2 DE), mass spectrometry and bioinformatics techniques, it was found that a variety of proteins (such as CagA, GroEL, TsaA, etc.) are related to the mechanism of gastric carcinogenesis caused by Helicobacter pylori. Some gastric cancer cell lines and gastric cancer Tissue-specific proteins, such as ErbB3, annexinV, prohibitin, etc .; proved pyruvate kinase M2 protein and other gastric cancer drug-resistant protein.