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目的分析利奈唑胺治疗髓系白血病老年患者革兰阳性球菌感染的效果,从而为临床预防和诊治提供依据。方法随机选取2012年9月-2015年9月医院髓系白血病合并革兰阳性球菌感染患者20例为研究对象,按照治疗方法不同分为观察组及对照组,各10例,两组患者均给予头孢哌酮/舒巴坦治疗,观察组在此基础上联合应用利奈唑胺,分析利奈唑胺在老年髓系白血病合并革兰阳性球菌感染中的治疗效果。结果两组患者感染部位分布比较,差异无统计学意义;20例患者共检出病原菌30株,其中革兰阳性菌22株占73.33%,革兰阴性菌8株占26.67%,双重感染患者10例;观察组患者用药时间和体温恢复时间明显短于对照组,差异有统计学意义(P<0.05);观察组患者治疗有效率为90.00%,高于对照组80.00%,但差异无统计学意义;两组患者在治疗过程中均未出现药物相关心、肝功能异常者。结论利奈唑胺治疗老年髓系白血病合并革兰阳性球菌感染疗效显著,可以有效地缩短用药时间,体温恢复快,不良反应低,临床上值得推广。
Objective To analyze the effect of linezolid in the treatment of gram-positive cocci infection in elderly patients with myeloid leukemia, so as to provide the basis for clinical prevention and treatment. Methods Twenty patients with myeloid leukemia and gram-positive cocci infection in hospital from September 2012 to September 2015 were randomly selected for the study. According to the different treatment methods, the patients were divided into observation group and control group, with 10 cases in each group. Both groups were given Cefoperazone / sulbactam. The observation group was treated with linezolid, and the treatment effect of linezolid was evaluated in the patients with senile myeloid leukemia complicated with gram positive cocci infection. Results There were no significant differences in the distribution of infection sites between the two groups. Of the 20 patients, 30 strains of pathogens were detected, of which 22 strains were Gram-positive bacteria, accounting for 73.33%, 8 strains Gram-negative bacteria accounting for 26.67%, and 10 Cases; observation group patients medication time and body temperature recovery time was significantly shorter than the control group, the difference was statistically significant (P <0.05); observation group patients treatment efficiency was 90.00%, 80.00% higher than the control group, but the difference was not statistically significant Significance; two groups of patients in the course of treatment did not appear drug-related heart, liver dysfunction. Conclusion Linezolid treatment of senile myeloid leukemia combined with gram-positive cocci infection has significant curative effect, which can effectively shorten the medication time, rapid recovery of body temperature, low adverse reactions, and it is clinically worthy of promotion.