Recent studies have demonstrated that treatment with erythro?poietin (EPO) protects the CNS from a variety of insults. The purpose of this study was to examine the relationship between EPO and the phenomena of ischemic pre-conditioning. Transient retinal (HIOP) and cerebral (MCAo) ischemia was induced in the rat. Treatment with EPO resulted in significant reduction Recent studies have demonstrated that treatment with erythro? Poietin (EPO) protects the CNS from a variety of insults. The purpose of this study was to examine the relationship between EPO and the phenomena of ischemic pre-conditioning. Transient retinal (HIOP) and cerebral (MCAo) ische was induced in the rat. Treatment with EPO resulted in significant reduction