论文部分内容阅读
双重压制技术是比较可靠的制备药物释放体系的方法。此体系由药物片心并包压-聚合物层组成,后者作为控制释放膜。这种技术成功的关键在于能够得到紧密并具有通透性的聚合物包衣层,包衣材料应能溶胀,不成凝胶,也不崩解。作者选用具有上述特点的聚合物,用双重压制技术制备胶囊型零级药物释放体系。并压成不同厚度的包衣膜,在不同pH,动力学条件下进行体外溶解特性的试验。将不同厚度的聚乙烯醇(PVA)作聚合物,分别直接压包在二羟丙茶碱(Diprophylline),西米替丁,盐酸西米替丁,苯酮苯丙酸钠(Ketoprofen)4种具有不同溶解度,pKa 等特性的药物核心外。核心是由5%PVP醇溶液与药物制成30目的颗粒压成片心。PVA 的用量从75至300mg 不等。片心的重量则依释放系统的直
Dual-pressing technology is a more reliable method of preparing drug delivery system. This system consists of a drug core and a pressure-polymer layer, the latter acting as a controlled release film. The key to the success of this technology is the ability to obtain a tight and permeable polymer coating that should swell, gel, and disintegrate. The author chose the polymer with the above characteristics, using double compression technology to prepare capsule zero-order drug delivery system. And pressed into different thickness of the coating film, in different pH, kinetic conditions in vitro dissolution characteristics of the test. Polyvinyl alcohol (PVA) of different thickness was used as polymer, which were directly compressed and packed in 4 kinds of diprophylline, cimetidine, cimetidine hydrochloride and Ketoprofen With different solubility, pKa and other characteristics of the drug core. The core is made of 5% PVP alcohol solution and the drug made into a 30-mesh granule into tablets. PVA dosage from 75 to 300mg range. Heart weight is based on the release of the system straight