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本文就高剂量率急性一次(223mGy/min)、分次累积(223mGy/min,每周照射一次,0.25Gy/次)及低剂量率慢性连续(每周照射5天,50mGy/d)γ射线照射时,在0—2Gy 累积剂量范围内,对猕猴造血、免疫及细胞遗传学方面某些生物效应进行了比较研究。不同方式照射时机体损伤程度和特性不一,急性照射组各类效应均比其它受照组明显;而分次和慢性照射组的剂量-效应规律则比较相似。在低剂量率慢性照射情况下,PHA 激活淋巴细胞微核、淋巴细胞染色体无着丝点断片及总断裂数在累积剂量为0.25Gy 时就出现了明显增高(p<0.05),且与受照剂量呈线性正相关。它们的剂量-效应曲线尾部(在1—2Gy 区)均呈现有“坪”的现象。停照后一年中动态观察的结果表明,各照射组动物受照时所诱发的效应,绝大多数是可恢复的。急性组恢复至正常所需时间较其它组长,其中免疫和造血机能的恢复呈显著波动性,而细胞遗传学效应随停照后时间的延长逐步恢复。
The aim of this study was to investigate the effects of high dose rate γ-ray (223 mGy / min), fractional accumulation (223 mGy / min, once weekly and 0.25 Gy / At irradiation, some biological effects on hematopoiesis, immunity and cytogenetics in macaques were compared over a cumulative dose range of 0-2 Gy. Different types of exposure to different degrees of injury and the body damage, acute irradiation group all kinds of effects were significantly more than other irradiated group; while the dose and effect of the rule group were relatively similar. In chronic irradiation of low dose, PHA-activated lymphocytes micronuclei, lymphocyte chromosomes without centromere fragments and the total number of rupture at a cumulative dose of 0.25Gy appeared significantly higher (p <0.05), and compared with the irradiated The dose was linearly positive. Their dose-response curve tail (1-2Gy area) showed a “ping” phenomenon. The results of the dynamic observation in the year after the suspension of the operation showed that most of the effects induced by irradiation of animals in each irradiation group were recoverable. The recovery time of acute group was longer than that of other groups. The recovery of immune and hematopoietic function showed significant fluctuation, and the cytogenetic effect recovered gradually with the prolongation of the time after stopping.