AIM:Globus pharyngeus is not an uncommon symptom.Presently,its unclear dated pathophysiology remains unclearand the disease can not be evaluated correctly with routinediagnostic methods.The objective of this study is to establishthe normal values of pharyngeal and UES pressure,pharyngeal transit time in healthy volunteers and to comparethe differences between healthy volunteers and patients withglobus pharyngeus.METHODS:Twenty-four healthy volunteers and thirty-twopatients clinically diagnosed as globus pharyngeus enteredthe study.Pressures of pharynx and UES were measured.Pharyngeal transit time was measured by videofluoroscopicprocedure.RESULTS:Normal pressure of pharynx,and normal restingpressure of UES were 157.81±63.86 mmHg and 68.33±37.56 mmHg,respectively.The corresponding values inthe patients were 175.50±93.47 mmHg and 71.38±41.42mmHg.The pharyngeal transit time was 1.44±0.30 s innormal control group,among them there were 4 caseswith stasis of barium in the valleculae and one in the piriformsinus.No laryngeal penetration or aspiration was found.In the patient group,the pharyngeal transit time was 1.37±0.41s,among them there were 6 cases with stasis ofbarium in the valleculae and 5 in the piriform sinus.9 caseshad laryngeal penetration and 2 had aspiration.There wereno statistical differences of pressures of pharynx,UES andthe pharyngeal transit time between the two groups.Butthere was an association between laryngeal penetrationand globus pharyngeus.CONCLUSION: Radiographic examination of the pharynx show specific findings of pharyngeal dysfunction in patients with globus pharyngeus. UES pressure is normal in most patients. Hence, we find no role for UES hypertonicity as an etiologic factor in globus pharyngeus. AIM: Globus pharyngeus is not an uncommon symptom. Prelyly, its unclear dated pathophysiology remains uncleara the the disease can not be evaluated correctly with routinediagnostic methods. The objective of this study is to establish the normal values ​​of pharyngeal and UES pressure, pharyngeal transit time in healthy volunteers and to compare the differences between healthy volunteers and patients with globus pharyngeus. METHODS: Twenty-four healthy volunteers and thirty-twopatients clinically diagnosed as globus pharyngeus entered the study. Pressures of pharynx and UES were measured. Pharyngeal transit time was measured by videofluoroscopic procedures. RESULTS: Normal pressure of pharynx, and normal resting pressure of UES were 157.81 ± 63.86 mmHg and 68.33 ± 37.56 mmHg, respectively. These corresponding values ​​in patients were 175.50 ± 93.47 mmHg and 71.38 ± 41.42 mmHg. The pharyngeal transit time was 1.44 ± 0.30 s innormal control group, among them there were 4 caseswith stasis of barium in the valleculae and one in the piriformsinus. No laryngeal penetration or aspiration was found. In the patient group, the pharyngeal transit time was 1.37 ± 0.41s, among them there were 6 cases with stasis of barium in the valleculae and 5 in the piriform sinus.9 caseshad laryngeal penetration and 2 had aspiration.There wereno statistical differences of pressures of pharynx, UES and the pharyngeal transit time between the two groups.Butthere was an association between laryngeal penetration and globus pharyngeus. CONCLUSION: Radiographic examination of the pharynx show specific findings of pharyngeal dysfunction in patients with globus pharyngeus. UES pressure is normal in most patients. Therefore, we find no role for UES hypertonicity as an etiologic factor in globus pharyngeus.