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本文报告了黄夹甙、次甙甲和次甙乙对麻醉犬的血流动力学和器官血流量的作用,比较了黄夹甙成分和洋地黄制剂对实验性心力衰竭猫和豚鼠的强心效力和安全范围。结果表明,这些强心甙均有正性肌力作用,次甙乙收缩血管的作用不明显。以心力衰竭豚鼠治疗量为指标,强心作用顺序为黄夹次甙甲>次甙乙>黄夹甙>西地兰>地高辛。次甙甲的安全范围比洋地黄制剂大。用放射免疫法测定了心衰豚鼠静脉滴注黄夹甙、次甙甲和次甙乙达到治疗效力、中毒反应(心律失常)和死亡时的血药浓度,表明次甙甲的治疗和中毒浓度交叉很小。黄夹甙、次甙甲和次甙乙口服吸收快,生物利用度相似,次甙甲消除快(T 1/2 2.13 h,次甙乙除消较慢(T 1/2 6.79)。
This paper reports the effects of Huangjijiao, Xiejiajia, and Xiezhiyi on hemodynamics and organ blood flow in anesthetized dogs, and compared the cardiac potency of the ingredients of Huangqi Jia and Digitalis preparations on experimental heart failure cats and guinea pigs. And safety range. The results showed that these cardiac palsy have a positive inotropic effect, and the secondary vasospasm does not have a significant effect on vasoconstriction. Taking the treatment of heart failure guinea pigs as the index, the order of the cardiotonic effect was Huang Jia Xie Jia Jia> Xi Ji B> Huang Ji Xi> Cidiran> Digoxin. The safety range of secondary armor is greater than that of digitalis preparations. Radioimmunoassay was used to measure the plasma concentrations of ciprofloxacin, dipyridamole, and diterpene infusion in patients with heart failure guinea pigs for therapeutic efficacy, toxic response (arrhythmia), and death. The cross is small. The yellow peony root, the second peony root, and the second quinone ox were absorbed orally quickly, and their bioavailability was similar. The secondary armor elimination was faster (T 1/2 2.13 h, and the secondary quintile B elimination was slower (T 1/2 6.79).