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目的 探讨延髓最后区对胃肠消化间期移行性复合运动 (MMC)及血浆胃动素水平的影响。方法 在 8只犬的胃窦和十二指肠浆膜埋植应力传感器记录胃窦和十二指肠消化间期复合运动。在一侧股静脉内置慢性静脉插管供注射外源性胃动素。用RIA法测定血浆胃动素含量。观察 :(1)消化间期正常MMC活动和血浆胃动素浓度变化 ;(2 )电损毁延髓最后区对MMC活动和血浆胃动素水平的影响 ;(3)电损毁延髓最后区对外源性胃动素启动MMCⅢ相收缩作用的影响。结果 (1)正常犬消化间期出现典型的Ⅰ、Ⅱ、Ⅲ、Ⅳ相MMC。MMCⅢ相与血浆胃动素释放高峰同步发生。 (2 )电损毁延髓最后区后 ,胃窦和十二指肠MMC的收缩运动明显抑制 ,MMCⅠ相延长 ,Ⅱ、Ⅲ相明显缩短 ,失去了损毁前MMC周期性 时相性和移行性的特点 ,血浆胃动素浓度明显降低 ,外源性静脉注射胃动素不能启动MMCⅢ相收缩。结论 延髓最后区对消化间期MMC的周期发生和移行有重要的调控作用 ,其作用途径与胃动素介导有关。
Objective To investigate the effect of the medulla oblongata in the last stage on gastrointestinal motility and plasma motilin (MMC). Methods The stress sensors were embedded in the gastric antrum and the duodenum of 8 dogs to record the compound activity of gastric antrum and duodenum. A venous femoral vein was placed on one side for injection of exogenous motilin. Determination of plasma motilin by RIA method. (1) Changes of normal MMC activity and plasma motilin concentration during the interdigestive period; (2) Effect of electrosurgical decrement of the final region of medulla oblongata on MMC activity and plasma motilin; (3) Effect of Motilin on MMC Ⅲ Phase Contraction. Results (1) Typical Ⅰ, Ⅱ, Ⅲ, Ⅳ phase MMC appeared in normal dogs during the digestive cycle. MMC Ⅲ phase and plasma motilin peak occurs simultaneously. (2) The contractile activity of gastric antrum and duodenal MMC was significantly inhibited after electrical rupture of the medulla oblongata. The MMC Ⅰ phase was prolonged, the phases Ⅱ and Ⅲ were significantly shortened, and the periodicity and the transitional phase of MMC were lost. Plasma motilin concentration was significantly reduced, exogenous intravenous injection of motilin can not start MMC Ⅲ phase contraction. Conclusions The last region of the medulla oblongata plays an important role in the regulation of the occurrence and migration of MMC during the process of digestion. The mechanism of action is mediated by motilin.