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３３只大白鼠随机平分为３组：用药组、手术对照组、正常对照组，手术组及用药组均行双肾动脉狭窄术，用药组术后给予钙拮抗剂心痛定。术前、术后的血压变化及术后第４周肾脏的病理变化结果显示：三组动物之间的血压变化有显著性意义（Ｐ＝０．０００），手术对照组大鼠血压升高最为明显，并随时间推移而逐渐升高；用药组肾脏较手术组及正常对照组损害轻、范围小。提示钙拮抗剂心痛定对双肾动脉狭窄高血压大鼠的血压及肾脏病理变化具有保护作用。
Thirty-three rats were randomly divided into three groups: the treatment group, the surgery control group, the normal control group, the surgery group and the medication group were given renal artery stenosis. The patients in the treatment group were given the calcium antagonist xintongding. Preoperative and postoperative blood pressure changes and pathological changes in the fourth week after operation showed that there was a significant difference in the blood pressure among the three groups of animals (P = 0.000). The blood pressure in the control group was the highest Obviously, and gradually increased over time; the treatment group than the operation group and the normal control group kidney damage, small range. It is suggested that calcium antagonist xintongding has a protective effect on blood pressure and renal pathological changes in hypertensive rats with renal artery stenosis.