李×,男,10个月。三个月始无明显诱因出现哭声嘶哑,腕、踝关节及手足小关节肿胀,伴有活动哭闹,不发热。曾在当地用强地松,钙剂无效来我院。以大骨节病收住。既往史无特殊。足月顺产第三胎,新法接生,母乳喂养,与同龄儿生长发育及智力发育均较迟缓。家族史无特殊。检查T36.8℃营养 Lee ×, male, 10 months. Three months no obvious incentive to appear crying hoarseness, wrist, ankle and hand, foot swollen joints, accompanied by activity of crying, no fever. Had strong pine in the local, invalid calcium to our hospital. We accept Kashin-Beck disease. No previous history. Full-term third trimester of birth, the new law delivery, breastfeeding, growth and development of children with the same age are relatively slow development of intelligence. No special family history. Check T36.8 ℃ nutrition