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The title compound,diisopropyl[(4-cyanopyrazol-3-ylamino)(2-hydroxylphenyl) -methyl] phosphonate was synthesized by the addition reaction of diisopropyl phosphite and N-(4-cyanopyrazole-3-yl) -2-hydroxylphenyl-imine. Its structure was characterized by IR,1H NMR,elemental analysis and single-crystal X-ray diffraction. The crystal belongs to the triclinic system,space group P1 with a = 9.1840(13) ,b = 9.2278(13),c = 12.1952(17) ,α = 93.846(2) ,β = 90.947(2) ,γ = 111.289(2) °,V = 959.9(3) 3,Dc = 1.309 g/cm3,Z = 2,μ(MoKa) = 0.173,F(000) = 400,the final R = 0.0414 and wR = 0.1196 for 2985 observed reflections(I > 2σ(I)) . The pyrazole and benzene moieties are approximately coplanar in each case. The dihedral angle between planes 1 and 2 is 82.99°. The crystal structure is stabilized by three intermolecular hydrogen bonds of O(1) -H(1) …O(2) ,N(2) -H(2) …N(3) and N(2) -H(2) …O(1) . Preliminary bioassay indicated that the title compound possessed antiviral activity to some extent.
The title compound, diisopropyl [(4-cyanopyrazol-3-ylamino) (2-hydroxphenylphenyl) -methyl] phosphonate was synthesized by the addition reaction of diisopropyl phosphite and N- (4-cyanopyrazole- The structure was characterized by IR, 1H NMR, elemental analysis and single-crystal X-ray diffraction. The crystal belongs to the triclinic system, space group P1 with a = 9.1840 (13), b = 9.2278 = 12.1952 17, α = 93.846 (2), β = 90.947 (2), γ = 111.289 (2) °, V = 959.9 (3) 3, Dc = 1.309 g / cm3, Z = 2, μ (MoKa) = 0.173, F (000) = 400, the final R = 0.0414 and wR = 0.1196 for 2985 observed reflections (I> 2σ (I)). The dirazole and benzene moieties are approximately coplanar in each case. The dihedral angle The crystal structure is stabilized by three intermolecular hydrogen bonds of O (1) -H (1) ... O (2), N (2) -H (2) ... N (3) and N (2) -H (2) ... O (1). Preliminary bioassay indicated that the title compound possessed antiviral activity to some extent.