巨噬细胞移动抑制因子(MIF)是一种重要的多功能细胞因子,参与多种病理生理学过程。越来越多的证据表明,MIF在巨噬细胞参与调节的各种疾病,尤其是在动脉粥样硬化中起着重要作用。文章主要就MIF的发现、结构、来源、生物学功能,特别是在动脉粥样硬化及其相关疾病中的作用做了综述。 Macrophage migration inhibitory factor (MIF) is an important multifunctional cytokine involved in a variety of pathophysiological processes. There is growing evidence that MIF plays an important role in various diseases in which macrophages are involved in regulation, especially in atherosclerosis. This review summarizes the findings of MIF, its structure, its origin, and its biological functions, especially its role in atherosclerosis and related diseases.