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丙型肝炎病毒（ＨＣＶ）核心区是对ＨＣＶ进行基因和血清分型的靶基因区。核心区存在ｑｕａｓｉｓｐｅｃｉｅｓ，这可能是ＨＣＶ逃避宿主的免疫应答而选择性突变的结果。在ＨＣＶ致病机理中，细胞免疫反应的损伤机理可能比病毒的直接作用更重要。核心区也是从基因水平上治疗ＨＣＶ感染和进行疫苗研究的重要区域。
The Hepatitis C virus (HCV) core region is the target gene region for genotyping and serotyping of HCV. The presence of quasispecies in the core region may be the result of selective mutations that HCV escapes the host’s immune response. In the pathogenesis of HCV, the mechanism of cellular immune response damage may be more important than the direct effect of the virus. The core region is also an important area for HCV infection and vaccine research at the genetic level.