作者首先报告4例患者,其中3例女性,均呈无痛性慢性钙化性胰腺炎,另1例男性为急性复发性胰腺炎。患者均有慢性间质性肾炎伴肾功能衰竭。所有4例均有长期滥用非那西汀史。作者认为上述4例患者有下列特点:(1)胰腺炎和肾功能衰竭发病时间甚为接近。(2)肾功能衰竭较轻,进展较慢,血清肌酊值和其他肾功能试验仅轻度受损。过去均无肾脏病史。(3)肾脏病变非继发于胰腺炎。(4)患者无肝炎或肝硬化,亦无自身免疫或血管因素可同时累及胰腺和肾脏。(5)间质性肾炎的诊断基于临床特点、实验室检查结果和形态学,其中2例且曾经尸检,诊断肯定,和文献所载非那西汀性间质性肾炎的检验结果完全符合。(6)未能找到其他胰腺炎病因如饮酒等。2例尸检者未能发现胰腺炎的其他病因。(7)根据大量文献复习,作者认为在慢性胰腺炎时,肾脏可出现轻度或中度动脉改变或小动脉性肾硬化,但未能见到类似本文4例的肾脏病变。(8)3例患者血清甘油三酸酯较高,似系慢性肾功能衰竭的后果,而不是胰腺炎的病因。经适 The authors first reported 4 patients, 3 of whom were women with painless chronic calcific pancreatitis and the other 1 with acute recurrent pancreatitis. Patients have chronic interstitial nephritis with renal failure. All 4 patients had long history of abuse of phenacetin. The authors believe the above 4 patients have the following characteristics: (1) The incidence of pancreatitis and renal failure is very close. (2) less severe renal failure, progress is slow, serum tincture and other renal function tests were only mildly impaired. No history of kidney disease in the past. (3) kidney disease secondary to pancreatitis. (4) patients without hepatitis or cirrhosis, no autoimmune or vascular factors can affect the pancreas and kidneys. (5) The diagnosis of interstitial nephritis based on clinical features, laboratory findings and morphology, of which 2 cases and had autopsy, the diagnosis affirmed, consistent with the test results of phenacetin interstitial nephritis contained in the literature. (6) failed to find other causes of pancreatitis such as alcohol and so on. 2 cases of autopsy failed to find other causes of pancreatitis. (7) According to a large number of literature review, the authors believe that in chronic pancreatitis, the kidneys may have mild or moderate arterial changes or arteriolar renal sclerosis, but failed to see similar to the four cases of renal disease. (8) The higher serum triglycerides in 3 patients seemed to be the result of chronic renal failure rather than the etiology of pancreatitis. After fitness