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目的:观察吸收性明胶海绵微粒联合碘化油经肝动脉栓塞(TACE)治疗原发性肝癌的疗效。方法:选择中晚期原发性肝癌152例,随机分为对照组和观察组各76例。对照组采用丝裂霉素+阿霉素+5-氟尿嘧啶+碘化油行TACE治疗,观察组在对照组治疗基础上加用吸收性明胶海绵微粒行TACE治疗。比较两组1年、2年、3年时肿瘤直径、甲胎蛋白(AFP)水平、总有效率及生存率。结果:观察组1年、2年、3年肿瘤直径、AFP水平、总有效率及生存率,分别显著或非常显著小、低、高、高于对照组(P<0.05,P<0.01)。结论:吸收性明胶海绵微粒联合碘化油行TACE治疗肝癌疗效优于碘化油行TACE治疗。
Objective: To observe the efficacy of absorbent gelatin sponge particles combined with iodized oil in the treatment of primary liver cancer by transcatheter arterial chemoembolization (TACE). Methods: Fifty-two patients with primary hepatocellular carcinoma of middle and late stage were selected and randomly divided into control group and observation group with 76 cases each. The control group with mitomycin + doxorubicin + 5-fluorouracil + iodized oil TACE treatment group in the control group based on the treatment with absorbent gelatin sponge particles TACE treatment. Tumor diameter, AFP level, total effective rate and survival rate were compared between two groups at 1 year, 2 years and 3 years. Results: The tumor diameter, AFP level, total effective rate and survival rate of the observation group at one year, two years and three years were significantly or very significantly smaller, lower, higher and higher than those of the control group (P <0.05, P <0.01). Conclusion: TACE treatment of hepatocellular carcinoma with absorbent gelatin sponge particles combined with iodized oil is superior to TACE treatment of iodized oil.