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目的 为探讨抵克立得 (盐酸噻氯匹定 )对老年糖尿病肾病患者血液流变学及尿白蛋白的影响。方法 将 6 2例老年糖尿病肾病患者根据尿白蛋白排泄率分为早期糖尿病肾病组和糖尿病肾病组 ,再进一步分为抵克立得治疗组和对照组。结果 发现糖尿病肾病患者全血粘度 (低切、高切 )、血浆粘度、纤维蛋白原显著上升。给予抵克立得治疗后 ,治疗组与对照组比较 ,治疗组各项指标显著改善 ,早期糖尿病肾病组尿白蛋白显著下降 ,临床糖尿病肾病组尿白蛋白排泄率无显著下降。结论 早期糖尿病肾病患者应及时应用降低血液粘稠度药物。
Objective To investigate the effect of ticlopidine (ticlopidine hydrochloride) on hemorheology and urinary albumin in elderly patients with diabetic nephropathy. Methods Sixty two elderly patients with diabetic nephropathy were divided into early diabetic nephropathy group and diabetic nephropathy group according to the urinary albumin excretion rate, and further divided into two groups: treated group and control group. The results showed that diabetic patients with whole blood viscosity (low-cut, high-cut), plasma viscosity, fibrinogen increased significantly. After the treatment of rodenticide, the treatment group compared with the control group, the treatment group significantly improved the indicators, urinary albumin in early diabetic nephropathy significantly decreased urinary albumin excretion rate of diabetic nephropathy group no significant decline. Conclusion Early patients with diabetic nephropathy should be timely application of drugs to reduce blood viscosity.