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目的:研究吲哚胺2,3双加氧酶(IDO)在上皮性卵巢癌组织中的表达及其与预后的相关性。方法:通过免疫组化的方法测定IDO在卵巢良性上皮性肿瘤、交界性上皮性肿瘤和恶性上皮性肿瘤组织中的表达。结果:IDO在卵巢恶性肿瘤中表达显著高于卵巢良性肿瘤(P<0.05)。IDO的表达与组织学分级显著相关(P<0.05)。IDO的阳性表达在复发和死亡组中明显高于生存组(P<0.05)。IDO(+)者的生存率曲线、平均生存时间明显低于IDO(-)者(P<0.05)。结论:低分化、高度恶性的卵巢癌细胞更可能表达IDO,IDO阳性表达与卵巢癌不良预后显著相关。
Objective: To investigate the expression of indoleamine 2,3 dioxygenase (IDO) in epithelial ovarian cancer and its relationship with prognosis. Methods: The expression of IDO in ovarian benign epithelial tumors, borderline epithelial tumors and malignant epithelial tumors was determined by immunohistochemistry. Results: The expression of IDO in ovarian cancer was significantly higher than that in benign ovarian tumor (P <0.05). The expression of IDO was significantly associated with histological grade (P <0.05). The positive expression of IDO in recurrence and death group was significantly higher than that in survival group (P <0.05). The survival rate curve of IDO (+) patients with mean survival time was significantly lower than that of IDO (-) patients (P <0.05). CONCLUSION: IDO is more likely to be expressed in poorly differentiated and highly malignant ovarian cancer cells. The positive expression of IDO is significantly associated with poor prognosis of ovarian cancer.