我们对121例肝硬化患者血清甲胎蛋白(AFP)含量进行了4年的动态观察,分析其变化特点,探讨其肝硬化患者血清AFP含量的变化与肝癌发生的关系,为肝癌的早期诊断和预防肝硬化后肝癌提供依据。 1 材料与方法 全部患者均为我科门诊或住院病人,121例肝硬化患者中男74例,女47例,平均年龄48.5岁。均符合第5次全国病毒性肝炎会议讨论的肝硬化诊断标准,19例经肝穿病理证实。其中乙型肝炎后肝硬化98例,丙型肝炎后肝硬化16例,酒精性肝硬化4例,病因不明者3例。肝硬化病史均在2年左右。在随访期间 We observed 121 cases of AFP in serum of patients with cirrhosis for 4 years and analyzed the changes of serum AFP levels in patients with cirrhosis and the relationship between serum AFP levels and the occurrence of hepatocellular carcinoma. Prevention of liver cirrhosis provide the basis for liver cancer. 1 Materials and Methods All patients were outpatients or inpatients in our department, 121 patients with liver cirrhosis in 74 cases, 47 females, mean age 48.5 years. All were in line with the 5th national hepatitis meeting discussed cirrhosis diagnostic criteria, 19 cases confirmed by liver biopsy. Among them, there were 98 cases of post-hepatitis B cirrhosis, 16 cases of post-hepatitis C cirrhosis, 4 cases of alcoholic cirrhosis and 3 cases of unknown etiology. The history of cirrhosis are about 2 years. During follow-up