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目的:观察广藿香油对实验性小鼠急性细菌性上呼吸道感染模型的影响。方法:采用耐甲氧西林金黄色葡萄球菌感染小鼠,以广藿香油防治后,观察小鼠鼻黏膜、气管和肺组织病理形态改变以及小鼠鼻咽部耐甲氧西林金黄色葡萄球菌菌落数的变化。结果:广藿香油可减轻耐甲氧西林金黄色葡萄球菌致急性上呼吸道感染(AURI)模型小鼠鼻黏膜组织病理形态改变,减少红细胞渗出及炎性细胞浸润。滴鼻感染后小鼠鼻咽部耐甲氧西林金黄色葡萄球菌(MRSA)菌落数量明显升高,而广藿香油各剂量组(12.65,6.325,3.1625×10-3g/kg)对其均有显著抑制作用。结论:广藿香油对耐甲氧西林金黄色葡萄球菌致急性上呼吸道感染模型小鼠有一定的防治作用。
Objective: To observe the effect of patchouli oil on acute bacterial upper respiratory tract infection in mice. Methods: Mice were inoculated with methicillin-resistant Staphylococcus aureus and treated with patchouli oil. The pathological changes of nasal mucosa, trachea and lung were observed in mice and the methicillin-resistant Staphylococcus aureus Number of changes. Results: Patchouli oil could alleviate the pathological changes of nasal mucosa in mice with methicillin - resistant Staphylococcus aureus (AURI) infection and reduce erythrocyte exudation and inflammatory cell infiltration. After nasal infection, the number of MRSA colonies in nasopharynx of mice increased significantly, while the dose of patchouli oil (12.65, 6.325, 3.1625 × 10-3g / kg) Significant inhibitory effect. CONCLUSION: Patchouli oil has some preventive and therapeutic effects on the mice model of acute upper respiratory tract infection caused by methicillin-resistant Staphylococcus aureus.