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目的对比分析西格列汀片和二甲双胍片分别联合精蛋白重组赖脯胰岛素治疗2型糖尿病的临床疗效。方法选取2014年10月—2016年2月期间潮安区人民医院门诊收治糖尿病2型患者80例,随机分为观察组与对照组,每组40例。所有患者均在精蛋白重组赖脯胰岛素基础上,对照组患者加用采二甲双胍片治疗,观察组患者加用西格列汀片治疗,所有患者治疗周期均为16周。比较两组患者治疗后血糖控制、胰岛功能改善以及低血糖情况发生率。结果经过治疗后,两组患者血糖控制情况比较,观察组空腹血糖、餐后2 h血糖以及糖化血红蛋白水平较对照组显著下降(P<0.05);观察组患者胰岛素抵抗指数较对照组显著下降,分泌指数显著上升(P<0.05);两组患者低血糖发生情况无明显差异(P>0.05)。结论采用西格列汀片联合精蛋白重组赖脯胰岛素可有效控制2型糖尿病血糖波动情况,改善胰岛细胞功能,降低胰岛素使用量,安全有效。
Objective To compare and analyze the clinical efficacy of sitagliptin and metformin in the treatment of type 2 diabetes mellitus with albumin and insulin lispro respectively. Methods From October 2014 to February 2016, 80 patients with type 2 diabetes admitted to the People’s Hospital of Chaoan District were randomly divided into observation group and control group with 40 cases in each group. All patients were on the basis of protamine recombinant insulin lispro, the control group plus metformin tablets, the observation group plus sitagliptin tablets, all patients were treated for 16 weeks. Blood glucose control, islet function improvement and incidence of hypoglycaemia were compared between the two groups after treatment. Results After treatment, the fasting blood glucose, 2h postprandial blood glucose and glycosylated hemoglobin in the two groups were significantly lower than those in the control group (P <0.05). The insulin resistance index in the observation group was significantly lower than that in the control group The secretion index increased significantly (P <0.05). There was no significant difference in hypoglycemia between the two groups (P> 0.05). Conclusion The combination of sitagliptin tablet and protamine recombinant insulin lispro can effectively control the type 2 diabetes, blood glucose fluctuations, improve islet cell function, reduce insulin dosage, safe and effective.