近年来的研究工作表明,内源性阿片肽与休克密切相关。在内毒素性休克、低血容量性休克和脊髓损伤性休克时,血浆和脑脊液中内源性阿片肽有不同程度的升高,应用阿片肽受体拮抗剂纳洛酮可对抗休克。我们在烫伤休克的研究中观察到,大鼠烫伤后,某些脑区和血浆中强啡肽A(1-13)[DynA(1-13)]免疫活性物质的含量有显著变化,烫后外周静脉给予DynA(1～13)抗血清,可改善大鼠心血管功能,延长存 In recent years, research shows that endogenous opioid peptide is closely related to shock. In endotoxic shock, hypovolemic shock and spinal cord injury shock, endogenous opioid peptides in plasma and cerebrospinal fluid increased to varying degrees. Naloxone, an opioid receptor antagonist, can counteract the shock. In the study of scalded shock we observed significant changes in the content of dynorphin A (1-13) [DynA (1-13)] immunoreactive substance in some brain regions and plasma after scald in rats, Peripheral intravenous administration of DynA (1 ~ 13) antiserum can improve cardiovascular function and prolong survival in rats