己烯雌酚(DES)是一种合成的非甾类雌激素。1971年 Herbst 等首次报道妊娠期间使用大剂量 DES 会导致其后代发生阴道腺癌。其后不少研究证实,有 DES 暴露的后代可产生广泛的生殖和妇科学问题,其中包括阴道和宫颈的结构改变,甚至发生鳞状化生。然而,在啮齿动物中虽已证明DES 是一种致癌物,但细菌诱变试验却为阴性。另 Diethylstilbestrol (DES) is a synthetic non-steroidal estrogen. In 1971 Herbst et al. First reported that the use of large doses of DES during pregnancy resulted in vaginal adenocarcinoma of their offspring. Subsequent studies have confirmed that offspring with DES exposure can produce a wide range of reproductive and gynecological problems, including vaginal and cervical structural changes, and even the occurrence of squamous metaplasia. However, DES has been shown to be a carcinogen in rodents, but the bacterial mutagenesis test is negative. another