论文部分内容阅读
目的:研究Gal-3与Bcl-2、层粘连蛋白受体(LR)在胰腺癌中的表达,并探讨它们与胰腺癌的发生、发展与转移的关系以及Gal-3与Bcl-2、LR在胰腺癌中的表达之间的关系及意义。方法:应用免疫组织化学技术S-P法检测胰腺癌组织中Gal-3、Bcl-2、LR等3种蛋白质的表达,并与3者在良性胰腺组织中的表达进行对照,采用四格表x~2检验对结果进行统计学分析。结果:(1)在68例胰腺癌组织标本中,Gal-3、Bcl-2、LR表达的阳性率分别为81％(55/68)、48.5％(33/68)、55.4％(37/68)。30例良性病变胰腺组织中,Gal-3呈无或弱表达,而LR和Bcl-2呈阳性或强阳性表达,表达率各为40％(12/30)、76.7％(23/30)、83.3％(25/30),与在胰腺癌中的表达相比,Gal-3的表达水平明显下降(P<0.01),Bcl-2与LR的表达显著升高(P<0.01、P<0.05)。(2)3者的阳性表达都与癌组织的分化程度无关。Gal-3在转移灶中的表达水平显著升高(P<0.05)。Gal-3的表达随着肿瘤的进展而增强,Bcl-2、LR的表达则减弱。结论:Gal-3可能与胰腺癌的发生发展及转移有关,而Bcl-2、LR可能是维持细胞正常活动的重要因子。
OBJECTIVE: To investigate the expression of Gal-3, Bcl-2 and laminin receptor (LR) in pancreatic cancer, and to explore their relationship with the occurrence, development and metastasis of pancreatic cancer and the relationship between Gal-3 and Bcl- In pancreatic cancer and its significance. Methods: The expression of Gal-3, Bcl-2, LR and other proteins in pancreatic cancer tissues was detected by immunohistochemical SP method and compared with the expression of 3 in benign pancreatic tissues. 2 test for statistical analysis of the results. Results: (1) The positive rates of Gal-3, Bcl-2 and LR were 81% (55/68), 48.5% (33/68) and 55.4% (37/68) respectively in 68 cases of pancreatic cancer. 68). In 30 cases of benign pancreatic lesions, Gal-3 was found to be either weak or weakly expressed, while LR and Bcl-2 were positive or strongly positive, with rates of 40% (12/30) and 76.7% (23/30), respectively 83.3% (25/30). The expression of Gal-3 was significantly lower than that of pancreatic carcinoma (P <0.01), while the expression of Bcl-2 and LR was significantly increased (P <0.01, P <0.05 ). (2) The positive expression of 3 had nothing to do with the differentiation of cancer tissue. The expression of Gal-3 in metastasis was significantly increased (P <0.05). The expression of Gal-3 increased with tumor progression, and the expression of Bcl-2 and LR decreased. Conclusion: Gal-3 may be related to the development and metastasis of pancreatic cancer, while Bcl-2 and LR may be important factors in maintaining normal cell activity.