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近年非胰岛素依赖型糖尿病(NIDDM)分子遗传学研究的进展之一为发现线粒体基因突变糖尿病。1992年,Van den Ouweland等用分子生物学技术发现第一个线粒体tRNA~(Leu(UUR))基因nt3243 A—G突变糖尿病家系。其临床上呈母系遗传,部分伴神经性耳聋的不典型且病情较重的NIDDM,提示这可能是群体中常见NIDDM和
In recent years, one of the progresses in molecular genetics of non-insulin dependent diabetes mellitus (NIDDM) is the discovery of mitochondrial gene mutations in diabetes. In 1992, Van den Ouweland and other molecular biology techniques found the first mitochondrial tRNA ~ (Leu (UUR)) gene nt3243 A-G mutant diabetes pedigree. The clinically maternally inherited, atypical and severe NIDDM with some deafness, suggests that this may be the common group of NIDDM and