采用改良Franz扩散池考察盐酸利多卡因(1)柔性纳米脂质体和普通纳米脂质体对小鼠离体皮肤的累积渗透情况,结果前者9 h累积渗透量高于后者。将上述两种剂型分别非封闭性应用于小鼠皮肤进行在体鼠皮渗透性试验。结果表明,1柔性纳米脂质体组和1普通纳米脂质体组小鼠皮肤中的t max分别为5和60 min,且前者c max是后者的1.2倍。普通纳米脂质体组小鼠血浆内未检出药物,柔性纳米脂质体组在0.5和1 h时检出微量药物,但浓度低于有效浓度。 The modified Franz diffusion cell was used to investigate the cumulative penetration of lidocaine hydrochloride (1) flexible nano-liposomes and ordinary nano-liposomes into the skin of mice in vitro. The results showed that the cumulative permeation volume of the former was higher than the latter at 9 h. The above two formulations were applied to the mouse skin in a non-occlusive manner in vivo mouse skin permeability test. The results showed that the tmax in the skin of 1 flexible nanoliposome group and 1 ordinary nanoliposome group were 5 and 60 min, respectively, and the former cmax was 1.2 times of the latter. No drug was detected in the plasma of normal nanoliposome mice. The drug was detected in the flexible nanoliposome group at 0.5 and 1 h, but the concentration was lower than the effective concentration.