目的探讨茶叶防癌的免疫调节机理。方法用致癌剂４甲基亚硝胺１（３吡啶）１丁酮（ＮＮＫ）诱发小鼠肿瘤的实验模型，观察ＮＮＫ所致小鼠免疫功能的改变及绿茶（ＧＴ）、复合茶（ＭＴ）和茶多酚（ＴＰ）的保护作用。结果小鼠注射ＮＮＫ后，在观察的４周内，腹腔巨噬细胞吞噬功能、外周血白细胞化学发光、迟发型变态反应、脾细胞抗体生成细胞数、以及脾ＮＫ活性等免疫指标，与正常对照组比较均出现不同程度的增高或降低；而ＧＴ、ＭＴ和ＴＰ对所有这些免疫功能的不良改变有明显的保护作用。结论茶及其成分对ＮＮＫ诱发小鼠肿瘤过程中早期所致免疫功能的改变具有保护作用 Objective To explore the immune regulation mechanism of tea anti-cancer. Methods The experimental model of mice tumor induced by carcinogen 4methylnitrosamine1(3-pyridyl)1 butanone (NNK) was used to observe the changes of immune function and green tea (GT) in mice induced by NNK. , compound tea (MT) and tea polyphenols (TP) protection. RESULTS: After injection of NNK in mice, immunological indicators such as phagocytosis of peritoneal macrophages, leukocyte chemiluminescence in peripheral blood, delayed hypersensitivity, number of splenocyte antibody producing cells, and spleen NK activity were observed within 4 weeks of observation. The group showed a different degree of increase or decrease; and GT, MT and TP had a significant protective effect on all these adverse changes in immune function. Conclusion Tea and its components have protective effects on the changes of immune function induced by NNK-induced mice during the early stage of tumorigenesis