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目的 探讨细胞周期素Ｅ和ｐ５３ 的同时表达在早期胃癌进展中的意义。 方法 用免疫组化法检测９７ 例早期胃癌中细胞周期素Ｅ 和ｐ５３ 的表达。 结果 早期胃癌中细胞周期素Ｅ和ｐ５３ 的表达显著相关，二者的同时表达率为１９％ （１８／９７）。同时表达的早期胃癌中，平均肿瘤最长径（２２ ±１３） ｍｍ ，幽门部发生率３０％ （１５／５０），分化型占２６％ （１８／７０），淋巴管浸润率３５％ （１１／３１） ，均显著低于或高于对照组；淋巴结转移率３８％（５／１３） ，静脉管浸润率３９ ％（７／１８），均高于对照组。同时表达的１８ 例中，５ 年生存率仅为６１ ％（１１／１８），而细胞周期素Ｅ 与ｐ５３ 均阴性者５ 年生存率为９０％ （ Ｐ＝０－００４） 。 结论 细胞周期素Ｅ和ｐ５３ 的同时表达很可能参与和促进了早期胃癌的进展，对两者同时表达者应给予更积极的治疗。
Objective To investigate the significance of simultaneous expression of cyclin E and p53 in the progression of early gastric cancer. Methods Immunohistochemistry was used to detect the expression of cyclin E and p53 in 97 cases of early gastric cancer. Results The expression of cyclin E and p53 in early gastric cancer was significantly correlated. The simultaneous expression rate of both was 19% (18/97). In early gastric cancers that were simultaneously expressed, the average longest diameter of the tumors was (22 ± 13) mm, the incidence of pylorus was 30% (15/50), the differentiated type was 26% (18/70), and the lymphatic infiltration rate was 35% (11 /31), were significantly lower or higher than the control group; lymph node metastasis rate was 38% (5/13), and venous intubation rate was 39% (7/18), both higher than the control group. Of the 18 cases that were simultaneously expressed, the 5-year survival rate was only 61% (11/18), while the 5-year survival rate was 90% (P=0-004) for patients with negative cyclin E and p53. Conclusion The simultaneous expression of cyclin E and p53 may participate in and promote the development of early gastric cancer, and more active treatment should be given to both of them.