目的:探讨鼻咽癌放疗后致迟发性放射性脑病的临床特征。方法:对中南大学湘雅医院神经内科所收治的34例鼻咽癌放疗后致迟发性放射性脑病患者临床资料、治疗方法及预后进行回顾性研究。结果:34例迟发性放射性脑病患者的临床特征包括头痛、头晕、记忆力下降、精神异常、抽搐、复视、面瘫或面部麻木、听力下降、言语增多、肢体无力、走路不稳、肢端麻木等。头部MRIT1WI呈低信号,T2WI呈高信号,增强后呈不规则强化。34例均随访,其中死亡11例,占32.35%;现存活23例,17例伴有严重症状,生存质量差,占50%。结论:鼻咽癌放疗后致迟发性放射性脑病临床表现各异,患者预后较差,临床上需尽早诊断,积极治疗,定期随诊。 Objective: To investigate the clinical features of delayed radiation induced encephalopathy after radiotherapy of nasopharyngeal carcinoma. Methods: The clinical data, treatment and prognosis of 34 patients with delayed radiation induced encephalopathy after radiotherapy of nasopharyngeal carcinoma treated by Department of Neurology, Xiangya Hospital of Central South University were retrospectively studied. Results: The clinical characteristics of 34 patients with delayed radiation encephalopathy included headache, dizziness, memory loss, mental disorders, convulsions, diplopia, facial paralysis or facial numbness, hearing loss, speech increase, limb weakness, walking instability, Wait. Head MRIT1WI was low signal, T2WI was high signal, enhanced irregular enhancement. 34 cases were followed up, of which 11 cases died, accounting for 32.35%; 23 cases were alive, 17 cases with severe symptoms, poor quality of life, accounting for 50%. CONCLUSIONS: The clinical manifestations of delayed radiation encephalopathy after radiotherapy of NPC are different. The prognosis of patients with nasopharyngeal carcinoma is poor. Clinic should be diagnosed as soon as possible, actively treated and followed up regularly.