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氨基糖苷类抗生素均具耳毒性,其中一些主要侵犯螺旋器,引起双侧感音神经性耳聋,另一些主要侵犯迷路前庭,出现眩晕、呕吐等前庭系统症状。临床上常用之氨基糖苷类抗生素依其对耳蜗毒性大小排列,顺序是新霉素、卡那霉素、链霉素、庆大霉素。链霉素和庆大霉素对耳蜗的毒性虽低于前二者,由于该两种药物临床使用率较高,故其危害性并不逊于新霉素和卡那霉素。
Aminoglycoside antibiotics are ototoxic, some of which mainly infringe the helix, causing bilateral sensorineural deafness, while others mainly infringe the vestibular vestibular, dizziness, vomiting and other vestibular system symptoms. Clinical commonly used aminoglycoside antibiotics according to the size of their cochlea toxicity, the order of neomycin, kanamycin, streptomycin, gentamicin. Although the toxicity of streptomycin and gentamicin to the cochlea is lower than that of the former two, the harmful effects of the two drugs are not inferior to neomycin and kanamycin due to their high clinical usage rate.