论文部分内容阅读
1 围产期用药的特点1.1 妊娠期母体的药物体内过程特点药物进入孕妇体内后的动力学变化大体上与非孕妇女相同,但又不尽相同.诸如孕妇血容量增加,使药物分布容积随之增加;肾血流和肾小球滤过率增加,加快了药物的清除;肝血流量和雌激素水平增加亦增加了药物的代谢;以及胎盘的形成和通过胎盘转运胎儿等进行性的生理变化都可以使药物浓度降低.又如孕妇胃肠蠕动功能减弱,可减缓药物吸收速率,增加药物吸收程度和改变肝脏的“首过作用”,影响药物的吸收.
1 characteristics of perinatal medication 1.1 gestational maternal drug in vivo process characteristics The dynamics of drugs into pregnant women after the body is generally the same with non-pregnant women, but not the same, such as increased blood volume in pregnant women, the volume of drug distribution with Increased; renal blood flow and glomerular filtration rate increased to speed up the drug clearance; liver blood flow and estrogen levels also increase the metabolism of drugs; and the formation of the placenta and transfer of the fetus through the placenta and other progressive physiological Changes can make the drug concentration decreases .As another example, pregnant women, gastrointestinal motility weakened, can slow the rate of drug absorption, increase the degree of drug absorption and change the liver “first pass”, affecting the absorption of drugs.