Objective: To observe the clinical efficacy of acupotomology in the treatment of cervical and shoulder myofascial pain trigger point for cervical radiculopathy , and to detect its effect on COX-2, PGE2,5-HT,TNF-α and other inflammatory factors. Methods: A total of 110 CSR patients were selected as the research objects and divided into observation group (Acupotomology to release the trigger points of myofascial pain in neck and shoulder combined with “three-stage” dialectical traction method) and control group (conventional acupuncture combined with “Stage 3” dialectical traction) with 55 cases.Before and after treatment, the two groups were compared by improving the efficacy of MacNab, simplifying the SCORE of Mc Gill Pain Scale, measuring cervical curvature and serum levels of inflammatory factors such as COX-2, PGE2, 5-HT and TNF-α. Results: After two weeks of treatment, the total effective rate of the observation group was 96.36％, higher than that of the control group (83.63％), and the difference was statistically significant (P < 0.05). After the treatment, PRI, VAS, PPI and other scores of the two groups were all lower than those before the treatment, with statistical significance (P 0.05).The serum inflammatory factors of coX-2, PGE2, 5-HT and TNF-α in the two groups were significantly lower after treatment than before treatment (P 0.05).The cervical curvature values measured after treatment were significantly increased compared with those before treatment, and the difference was statistically significant (P 0.05). Conclusion: The combination of acumotomology and “three-stage” dialectical traction method can significantly improve the pain and discomfort of patients with cervical radiculopathy, significantly reduce the symptoms, restore the physiological curvature of cervical vertebra, and reduce the inflammatory factors in serum.