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目的:探讨慢性乙型肝炎(CHB)患者血清IL18、IFNγ水平的变化及其临床意义。方法:应用ELISA法检测49例CHB患者血清IL18、IFNγ水平,并同时检测肝功能和乙肝病毒标志物。结果:CHB患者血清IL18、IFNγ水平均显著高于对照组(P<0.001),其升高水平依次为重度>中度>轻度,以CHB重度增高最为显著;血清IL18、IFNγ水平与血清ALT、TBil呈正相关(P<0.01或P<0.05);HBeAg阴性组血清中IL18水平较HBeAg阳性组明显升高(P<0.001),而IFNγ则无明显变化。结论:血清IL18、IFNγ参与了CHB的病理生理过程,并且与肝炎的病情变化密切相关,检测血清IL18、IFNγ水平有助于了解肝组织炎症活动及肝细胞损伤程度。同时,IL18在抗病毒方面发挥着重要作用。
Objective: To investigate the changes of serum IL18 and IFNγ levels in patients with chronic hepatitis B (CHB) and their clinical significance. Methods: The serum levels of IL18 and IFNγ in 49 patients with CHB were detected by ELISA, and liver function and hepatitis B virus markers were detected simultaneously. Results: Serum levels of IL18 and IFNγ in CHB patients were significantly higher than those in control group (P <0.001). The levels of serum IL-18 and IFN-γ in CHB patients were significantly higher than those in control group , And TBil (P <0.01 or P <0.05). The level of IL18 in serum of HBeAg-negative group was significantly higher than that of HBeAg-positive group (P <0.001), while IFNγ had no significant change. CONCLUSION: Serum IL18 and IFNγ are involved in the pathophysiological process of CHB, and are closely related to the changes of hepatitis. Detection of serum IL18 and IFNγ levels can help understand the inflammatory activity of liver tissue and the degree of hepatocellular injury. In the meantime, IL18 plays an important role in antivirus.