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通过临床与血清学检查,观察到两个亲戚的几个家庭成员患有系统红斑狼疮和其它自家免疫性疾病。A家庭中的6名直系成员中有3名患狼疮并且发现抗核抗体。B家庭8名成员中2名患有狼疮,3名发现有抗核抗体。对两户之家犬进行考察:A户为7岁杂种犬,在第一名家庭成员诊断狼疮前3年开始豢养。该犬背部有皮疹、脱毛。实验室试验显示高丙种球蛋白血症,较当地异常地增高,并且DNA变性。B户为4岁看羊狗,于家庭中有狼疮后10年才开始豢养。该犬曾有误诊为间歇热(Episodic fever)、多发性关节炎、白血球增多症的历史,同样有较当地增高的高丙种球蛋白血症及DNA变性。两只犬的抗核抗体及LE细胞均阴性。两个家庭狼疮成员的临床和血清学异常以及他们
Through clinical and serological tests, several family members of two relatives were observed with systemic lupus erythematosus and other autoimmune diseases. Three out of six immediate family members in family A had lupus and found antinuclear antibodies. Two of the eight B family members had lupus and three had anti-nuclear antibodies. The two-family dogs were investigated: A was a 7-year-old mongrel dog, who was raised in the first three years before being diagnosed with lupus. The back of the dog rash, hair removal. Laboratory tests show hypergammaglobulinemia, which is abnormally elevated locally and DNA denatures. B-year-old 4-year-old sheep dogs, lupus in the family after 10 years began to feed. The dog has been misdiagnosed as Episodic fever, polyarthritis, leukemia history of the same, there are also locally higher hypergammaglobulinemia and DNA degeneration. Antinuclear antibodies and LE cells in both dogs were negative. Clinical and serological abnormalities in both family lupus members as well as them