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本研究以人结肠癌SW－1116细胞体外培养后移植于Swiss－DF品系8周龄裸鼠双侧肾包膜下，次日以不同剂量天花粉蛋白（Trichosanthin，TCS）注射入裸鼠腹膜腔内。每天1次，连续5d，d8解剖裸鼠，观察天花粉蛋白对移植瘤体内抑制情况。结果显示：TCS剂量为0．75mg／kg组抑瘤率为41．2％（P＜0．01），优于丝裂霉素组（抑瘤率31．28％）0．5mg／kg组抑瘤率为27．5％（P＜0．05），远小于TCS对小鼠的半数致死量LD50（134mg／kg）。提示TCS体内应用安全度大，临床研究前景好。
In this study, human colon cancer SW-1116 cells were cultured in vitro and transplanted into the bilateral renal capsule of a Swiss-DF 8-week-old nude mice. The following day, different doses of Trichosanthin (TCS) were injected into the peritoneal cavity of nude mice. . The nude mice were dissected once a day for 5 days and d8, and the inhibitory effect of trichosanthin on tumor xenografts was observed. The results showed that: TCS dose of 0.75mg/kg group tumor inhibition rate was 41.2% (P <0.01), superior to mitomycin group (inhibition rate of 31.28%) 0.5mg/kg group The tumor inhibition rate was 27.5% (P<0.05), which was far less than the median lethal dose (LD50) of TCS in mice (134 mg/kg). It is suggested that the safety of TCS application in vivo is high and the clinical research prospects are good.