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胆囊动力低下是胆囊胆固醇结石的重要发病因素之一。据认为前列腺素是胆囊动力低下的一种重要介质。实验及临床研究表明,非甾体类抗炎药物(NSAID)能抑制前列腺素而防止高危人群的胆囊结石形成。作者研究了高、低剂量阿司匹林对健康人和胆石病人胆囊动力的影响。 方法:随机对照研究了20名健康志愿者(对照组)和30例胆囊结石病人(病人组)。病人组又随机分至三组,安慰剂组(Ⅰ)、阿司匹林350mg/天组(Ⅱ)和阿司匹林1400mg/天组(Ⅲ),每组10例。每天10pm(餐后)服药。
Gallbladder gallbladder cholesterol gallstone is one of the important risk factors. It is thought that prostaglandin is an important mediator of gallbladder motility. Experimental and clinical studies have shown that non-steroidal anti-inflammatory drugs (NSAIDs) can inhibit prostaglandins and prevent the formation of gallstones in high-risk groups. The authors investigated the effects of high and low-dose aspirin on gallbladder motility in healthy and gallstone patients. METHODS: Twenty healthy volunteers (control group) and 30 gallstone patients (patient group) were randomly assigned to control. The patients were randomized to three groups: placebo (Ⅰ), aspirin 350 mg / day (Ⅱ) and aspirin 1400 mg / day (Ⅲ), with 10 in each. Daily 10pm (after meal) medication.