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氧哌嗪青霉素(piperacillin,哌拉西林,PIPC)是第四代超广谱半合成青霉素。由于其抗菌谱广、副作用少,已在临床广泛应用。我们在治疗过程中发现其在较长时期用药后可出现寒战、发热及皮疹等副作用,今报道3例如下。例1 男,71岁。因慢性持续喘息60余年,加重2周于1992年1月20日入院。入院诊断为支气管哮喘,经氨茶碱等解支气管痉挛药物及青霉素640万U/d、PIPC6g/d静滴,急性哮喘发作减轻,但肺部仍可闻及散在哮鸣音。于使用PIPC之第31日起,每日午后出现畏寒、发热,体温38℃,3日后又升至39.4℃,白细胞计数为5×10~/L,中性
Piperacillin (piperacillin, piperacillin, PIPC) is the fourth generation of extended spectrum semisynthetic penicillins. Because of its wide antibacterial spectrum, fewer side effects, has been widely used in clinical. We found in the course of treatment in the longer period after treatment there may be chills, fever and rash and other side effects, reported 3 cases as follows. Example 1 male, 71 years old. Chronic continuous wheezing for more than 60 years, an aggravating two weeks in January 20, 1992 admission. Admission was diagnosed as bronchial asthma, aminophylline and other solutions of bronchospasm drugs and penicillin 6.4 million U / d, PIPC6g / d intravenous infusion, acute asthma attack reduced, but the lungs can still smell and scattered wheeze. On the 31st day after using PIPC, chills and fever occurred in the afternoon after noon. Body temperature was 38 ℃. After 3 days, the temperature rose to 39.4 ℃. The white blood cell count was 5 × 10 ~ / L, and the neutral