为了寻找高效、低毒的抗病毒剂，本文通过用腺嘌呤及嘧啶碱基与３氯２甲基丙烯缩合合成６个ＤＨＰＡ类似物的中间体５ａ，５ｂ，６～８ａ和８ｂ。应用ＯｓＯ４催化，在Ｎ甲基吗琳Ｎ氧化物氧化下对烯键进行邻位双羟化，合成了５个ＤＨＰＡ类似物１～４ａ，ｂ。对化合物５ａ，５ｂ，６～８ａ，８ｂ的１ＨＮＭＲ数据进行了初步总结。对４个ＤＨＰＡ类似物测定了它们对Ｓ腺苷Ｌ高半胱氨酸水解酶（ＳＡＨ）的抑制活性，其中化合物１的ＩＣ５０为１１ｍｍｏｌ·Ｌ－１，其余化合物均无抑制活性。 In order to find efficient and low toxicity antiviral agents, we synthesized intermediates 5a, 5b, 6 ~ 8a and 8b of six DHPA analogs by condensation of adenine and pyrimidine bases with 3chloro2methyl propylene. OsO4 catalyzed ortho-dihydroxylation of the olefinic bond in the presence of N-methylmorpholin  N  oxide to synthesize five DHPA analogs 1 ~ 4a, b. 1H NMR data of compounds 5a, 5b, 6 ~ 8a, 8b are preliminary summarized. Four DHPA analogs were tested for their inhibitory activity against S-adenosyl-L-homocysteine ​​hydrolase (SAH), with compound 1 having an IC50 of 1  1 mmol·L -1 without inhibition of the other compounds active.