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目的：探讨P53蛋白在滋养层细胞肿瘤发生发展的作用。方法：用免疫组化LSAB法观察P53蛋白在绒毛膜癌、侵袭性葡萄胎及葡萄胎组织中的表达。结果：P53在56例良性葡萄胎、51例侵袭性葡萄胎和47例绒毛膜癌中均有过表达，且后两者明显高于前者（P＜0．01）。还发现29例具有恶变潜能的葡萄胎其P53蛋白的表达明显高于未发生恶变者（P＜0．05）。结论：提示P53蛋白的过表达与滋养层细胞肿瘤的增殖有一定意义，可作为判断良性肿瘤恶性变及鉴别良恶性肿瘤的指标之一，从基因水平推测P53基因在良性葡萄胎恶性变、绒毛膜癌及侵袭性葡萄胎发生发展中起重要作用。
Objective: To investigate the role of P53 protein in the development of trophoblast tumors. Methods: The expression of P53 protein in choriocarcinoma, invasive hydatidiform mole, and hydatidiform mole were observed by immunohistochemical LSAB method. Results: P53 was overexpressed in 56 benign moles, 51 invasive moles and 47 choriocarcinomas, and the latter two were significantly higher than the former (P<0.01). It was also found that the expression of P53 protein was significantly higher in 29 cases of malignant moles with malignant potential than in those without malignant transformation (P<0.05). Conclusion: It is suggested that the over-expression of P53 protein has a certain significance in the proliferation of trophoblast cell tumors. It can be used as one of the indicators to judge benign tumor malignancy and differentiate benign and malignant tumors. From the gene level, it is supposed that P53 gene is malignant in benign hydatidiform mole. It plays an important role in the development of membrane cancer and invasive mole.